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The five important instruction set design issues are as listed below;

  1. Operation repertoire: How many and which operations to provide, and how complex operations should be. 
  2. Data types: The various types of data upon which operations are performed. 
  3. Instruction format: Instruction length (in bits), number of addresses, size of various fields, and so on. 
  4. Registers: Number of CPU registers that can be referenced by instructions, and their use. 
  5. Addressing: The mode or modes by which the address of an operand is specified.

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